Abstract
Sustainable development of drug delivery materials with good biocompatibility and controlled-release is a popular topic among researchers. In this research study, we demonstrated the potential of the metal-organic framework, that is MIL-100(Fe), as a drug delivery platform for isoniazid (INH). The MIL-100(Fe) was prepared by using the hydrofluoric acid-free hydrothermal method. Several physical measurements were conducted to characterize the MIL-100(Fe), including x-ray diffraction (XRD), scanning electron microscopy (SEM), nitrogen sorption, and thermal-gravimetric (TG). The synthesized MIL-100(Fe) has octahedron-shaped particles with superior properties, that is large surface area (1456.10 m2/g) and pore volume (1.25 cm3/g). The drug loading rate and capacity were determined by means of adsorption kinetic and isotherm. The studied INH@MIL-100(Fe) adsorption system kinetics follow the pseudo-first-order model, while the isotherm system follows the Langmuir model with the maximum adsorption capacity of 128.5 mg/g at 30 °C. MIL-100(Fe) shows adequate biocompatibility, also exhibits a reasonable and controlled drug release kinetics. The results obtained show that MIL-100 (Fe) can be a good choice of drug delivery platform among other available platforms.
Highlights
IntroductionIsoniazid (or isonicotinylhydrazide, abbreviated as INH) is a heterocyclic drug that contains N, which is known for its anti-mycobacterial properties for the treatment of Tuberculosis (TB)
Isoniazid is a heterocyclic drug that contains N, which is known for its anti-mycobacterial properties for the treatment of Tuberculosis (TB)
We investigated the potential application of MIL-100(Fe) to promote the loading and release of INH
Summary
Isoniazid (or isonicotinylhydrazide, abbreviated as INH) is a heterocyclic drug that contains N, which is known for its anti-mycobacterial properties for the treatment of Tuberculosis (TB). A controlled and sustained drug delivery system can help to reduce the side effects and increase the efficiency of the treatments It can prevent the emergence of drug-resistance species due to fluctuations in drug content will cause bacteria to lack time to adapt[9]. Despite the rapid development of biomaterials for drug delivery systems, the low drugs loading due to the materials small pore volume is still an unsatisfactory aspect[10] To overcome this drawback, a large pore volume material, namely metal-organic framework (MOF) have been utilized as drug delivery material[11,12]. The synthesized MIL-100(Fe) has a porous structure with a large surface area (~2000 m2·g−1 BET) and pore volume (~0.9 cm3·g−1)[11,12,15] Due to these advantageous properties of MIL-100(Fe), it has been proposed as a potential drug delivery system[12]. Several models for drug loading and release have been implemented and studied
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
