Abstract

In recent years, a number of new photosensitizers have been developed for the photo-dynamic treatment of cancer. These new drugs include tetrasulfonated phthalocyanines, tetra(hydroxypheny1) porphyrins, chlorins and purpurins which are water soluble, and phthalocyanines, chlorins, purpurins and verdins which are water insoluble. In vivo or in vitro data are available to assess the relative photodynamic efficiency of either hydrophobic or hydrophilic sensitizers. Hydrophobic drugs require a more complex delivery system in order to overcome their water insolubility. In this paper, we report the suitability of both oil-based emulsions and unilamellar liposomes for in vivo delivery of three different photosensitizers (a purpurin, a verdin and a chlorin).

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