Abstract
H2S modulates the chemosensory and respiratory response to hypoxia. We previously demonstrated H2S produced by cystathionine beta synthase (CBS) tonically augments synaptic transmission in nTS, the central site for chemosensory integration. Here, we sought to determine the role of H2S in nTS on respiratory, cardiovascular and autonomic parameters and their response to hypoxia. Phrenic (Phr) and splanchnic sympathetic nerve (sSNA) activity, as well as mean arterial pressure (MAP) and heart rate (HR) were evaluated in anesthetized rats exposed to brief hypoxia (10% O2, 2 min). Compared to control, bilateral nTS microinjection of the CBS activator, SAM (100 μM, 90 nL) had no effect on basal Phr frequency but increased Phr amplitude, MAP and sSNA. Hypoxia increased Phr and sSNA, consistent with chemoreflex activation. SAM also augmented sSNA, HR and Phr responses to hypoxia. By contrast, bilateral nTS microinjection of the CBS blocker AOA (1 mM, 90 nL) decreased Phr amplitude but not sSNA during hypoxia, suggesting an effect of endogenous H2S on hypoxic ventilatory responses in vivo. Altogether, these data suggest H2S modulates the cardiorespiratory system, in part, via its actions in the nTS. HL55306, HL085108.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
