Abstract
Seborrheic Keratosis (SK) is a common, benign epidermal tumor as observed by dermatologists. Removal is rarely indicated, and usually requested by patients for cosmetic preference. The most common method of removal is cryotherapy, but other topical treatments exist. Topical Hydrogen Peroxide has been recognized as an effective topical treatment. Safety concerns and maximum efficiency of peroxides have been a topic of study in a variety of dermatological conditions. This article aims to review the chemical composition of hydrogen peroxide (H202) in treating SK, methods to increase its effectiveness as a topical dermatological product, and explore the promising new FDA approved treatment.
Highlights
Seborrheic Keratoses (SK) are common, benign tumors of the epidermis that first appear most often in middle-aged men and women
A study completed by Roh et al concluded that the acanthotic subtype was the most prevalent among skin biopsies, with the adenoid type occurring most commonly on sun-exposed sites.Variations in the presentation of SK do exist, with the greatest concerns occurring with lesions that mimic premalignant or malignant epidermal tumors
The results showed that patients treated with Eskata observed total or near clearance of all SK lesions after two treatments, when compared with patients who received the placebo. 13.5% of patients treated with Eskata noted clearance of at least three of the four SK lesions, and in a follow-up study with an advanced clinical version of Eskata, the number rose to 23% of patients
Summary
Seborrheic Keratoses (SK) are common, benign tumors of the epidermis that first appear most often in middle-aged men and women. They can occur on any part of the body except for the palms and soles but often present on sun-exposed areas such as the face and forehead. A study completed by Roh et al concluded that the acanthotic subtype was the most prevalent among skin biopsies, with the adenoid type occurring most commonly on sun-exposed sites.Variations in the presentation of SK do exist, with the greatest concerns occurring with lesions that mimic premalignant or malignant epidermal tumors. Other common methods include shave excision, electro-dessication, topical treatment, or curettage [6]
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