Abstract
The kinetics of hydrogen-tritium exchange reactions have been followed, using a Sephadex technique, for a double-helical poly(ribo-N 6- methyladenylic acid)-poly(ribouridylic acid) complex. Only one (but not two) hydrogen in every N 6- methyladenine · uracil basepair has been found to exchange at a measurably slow rate (1.2 · 10 −3 s −1) at 0°C. Thus, the proton exchange between the adenine-amino and uracil-imide groups in a double-helical polynucleotide is considered to be not as fast as has been suggested previously (approx. 10 s −1) for an adenine · uracil basepair in a monomer system in a non-polar solvent.
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