Abstract
Hydrogen deuterium exchange mass spectrometry (HDX-MS) has become an increasingly routine technology for probing the solution structure and dynamics of proteins. HDX-MS measures the exchange of deuterium with the amide proton on the protein backbone chain. HDX-MS results can be used to aid in construct design for biophysical studies, to probe protein-ligand interactions and to characterize the dynamics of proteins. This digest highlights recent progress which makes this technology accessible and explores examples of HDX-MS in drug discovery and solution state structural biology.
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