Abstract

One biochemical approach to aging research has been to isolate bodily structural components, study their physiochemical properties, and establish the molecular basis for bodily changes during the aging process. This approach has been particularly fruitful in the field of connective tissue research, ever since soluble collagen was first isolated from tendon, and synthetic fibrils were reconstituted from the soluble collagen in vitro (1). When, in addition to soluble collagens and soluble ground substances, connective tissue components with high order structures, observable as collagen fibril, collagen fiber, and collagen fiber bundle (2) are isolated and characterized, such age-related changes as shrinkage temperature and tensile strength of skin (3) may be able to be expressed in terms of the physiochemical properties of their structural components.

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