Abstract
Objective: The objective of this study was to evaluate the effect of the hydroalcoholic extract of Matricaria Chamomilla Linn. (CHAE) on lipids, lipoproteins, and antioxidants activity in isoproterenol (ISO)-induced myocardial infarcted rats.
 Methods: ISO (85 mg/kg, s.c.)-induced myocardial infarction for 2 consecutive days at an interval of 24 h. Rats were pretreated with CHAE (100 and 200 mg/kg, oral) for a period of 20 days and ISO was injected on 21 and 22 days at 24 h intervals and after 24 h, blood was collected through retro-orbital plexus for the estimation of lipids, lipoproteins, and antioxidants assay.
 Results: In the present study, ISO caused a significant increase in the concentration of total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), very LDL-C, and lipid peroxidation whereas a significant decrease in the concentration of high-density lipoprotein-C. ISO administration also significantly decreased the activities of paraoxonase (PON) enzyme. Oral pre-treatment of CHAE at doses of 100 and 200 mg/kg body weight (bw) for 20 days challenged with a concurrent injection of ISO (85 mg/kg bw) on 21 and 22 days significantly attenuated these alterations and restored the levels of lipids and lipoproteins. In addition, CHAE significantly elevated the serum antioxidants enzyme PON and catalase (CAT).
 Conclusion: The report revealed that pre-treatment with CHAE ameliorated lipid and lipoprotein and increased the antioxidant PON and CAT activity and decreased LPO level in ISO-treated male albino Wistar rats.
Highlights
Myocardial infarction (MI) or heart attack is the leading cause of death for both men and women all over the world
MI occurs when blood supply is insufficient to the myocardium, death of myocardial muscle occurs, a condition known as ischemia
Rats injected with ISO exhibited a significant (p
Summary
Myocardial infarction (MI) or heart attack is the leading cause of death for both men and women all over the world. MI occurs when blood supply is insufficient to the myocardium, death of myocardial muscle occurs, a condition known as ischemia. Prolonged ischemia of the myocardium leads to necrosis of myocardium cell, which is referred to as MI [1]. MI is the acute condition that occurs due to imbalance between coronary blood supply and demand [2]. Cardiovascular diseases are directly or indirectly related to oxidative stress that causes molecular and cellular damage. Numerous medicinal plants have been evaluated for cardiovascular diseases in India and various parts of the world using cardiotoxic models [3]
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