Abstract
An impeller suspension mechanism is a major concern to avoid thrombus formation for long-term centrifugal pump application. A gyro-type centrifugal pump has been developed as permanent implantable ventricular assist device (VAD). Currently, this titanium-made gyro pump utilizes a novel hydraulic impeller suspension system. This study aims to evaluate the anti-thrombogenicity of the hydraulic suspension (HS) gyro pump. In vitro studies were conducted to examine the platelet adhesion at the bottom pivot, which is a primary lesion of white thrombus after pump implantation. For the pump hemorheology analysis, the particle tracing flow visualization was performed utilizing. In addition to these in vitro studies, current in-vivo animal studies were retrospectively examined.TableHS pumps demonstrated 50% lower platelet adhesion rate at the bottom pivot lesion compared to the control gyro pump. With the flow visualization study, continuous washout flow was created around the the center pivot behind the impeller. Total 20 pumps were implanted to 10 calves, and no thromboembolism was observed. Only one case had thrombus formation inside the right pump head due to low pump flow caused by the outflow graft kinking. This HS gyro pump is a compact, secure, and affordable VAD.
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