Abstract
In this paper, we reported a facile strategy to synthesize hyaluronic acid (HA) conjugated porous silica nanoparticles (pSiO2) as drug carrier. The pSiO2 were prepared by solid nano-silica nanoparticles with “surface-protected etching”. Morphologies of solid and porous silica nanoparticles were characterized by SEM and TEM. Amino groups were introduced on pSiO2 to graft HA as cancer targeting ligand. Then rifampicin used as model drug was loaded in pSiO2-HA. The results indicate that pSiO2 can perform a certain degree of slow release. Overall, the system might open the door to a new generation of carrier system for site-selective, controlled-release delivery of anticancer drugs.
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