Human T-Cell Leukemia/Lymphoma Virus: Studies of Host-Virus Interaction

Abstract

The human T-cell leukemia-lymphoma virus (HTLV) is a novel exogenous retrovirus (Poiesz et al. 1980, 1981; Gallo et al. 1982) recently found to be associated with adult T-cell leukemias in Japan (Yoshida et al. 1982; Haynes et al. 1982a), West Indies (Blattner et al. 1982; Catovsky et al. 1982), southeastern United States (Gallo et al. 1983a), Israel (Popovic et al. 1983), and other areas. Despite the diverse geographical clustering of HTLV-related leukemias and lymphomas, serological studies utilizing HTLV+ sera from patients with Japanese adult T-Cell leukemia (ATL), cutaneous T-cell lymphomas (CTCL), and T-cell lymphosarcoma cell leukemia (TLCL) have indicated that HTLV isolates from around the world are highly related (Popovic et al. 1982, 1983; Kalyanaraman et al. 1982a; Gallo et al. 1983a). Concordance between the primary structure of HTLV p24 predicted by sequence analysis of the HTLV provirus from Japanese ATL (Seiki et al. 1983) and the partial amino acid sequence of HTLV p24 from American ATL leukemia cells (Oroszlan et al. 1982), as well as nucleic acid homology (Wong-Staal et al. 1983) and shared proviral restriction enzyme cleavage sites between American and Japanese HTLV isolates, have prompted the adoption of terminology which defines the provirus of Japanese ATL as a strain (HTLVATL) of HTLV (Watanabe et al. 1983). In addition, a new type of HTLV designated as HTLV-II has been isolated from a patient (MO) with a T-cell variant of hairy cell leukemia (Kalyanaraman et al. 1982 b). Although the 24000-dalton core proteins of HTLV-I (also denoted here as HTLV) and HTLV-II are antigenically related, the restriction maps of HTLV-I and HTLV-II (MO) show few regions of overlap (Chen et al. 1983; Gelmann et al. 1984).KeywordsBovine Leukemia VirusHairy Cell LeukemiaThymic EpitheliumStaphylococcus Aureus CowanMedullary Thymic EpitheliumThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.