Abstract
Thymic development proceeds in stages whereby immature T-cell precursors lacking T-cell receptor (TCR) and CD4 and CD8 expression (double negative: DN), progress through a TCRlo CD4+CD8+ (double positive: DP) stage before differentiating into mature TCRhi CD4+CD8− or CD4−CD8+ (single positive: SP) thymocytes.1 DP thymocytes are subjected to positive and negative selection.2 Positive selection results in the development of a peripheral T-cell population capable of responding to antigen presented in the context of self major histocompatibility complex (MHC). Negative selection eliminates T cells with potentially harmful self-reactivity. This process is defined as clonal deletion. DP thymocytes which are not clonally deleted progress to a mature SP stage.
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