Abstract

The cytology of acute inflammation was originally described by Metchnikoff in experimental animals. Rebuck and Crowley (1) have advanced the technic of human skin windows which confirmed the description of the acute inflammatory cycle. The basic sequences consisted of an early migration of phagocytic granulocytes, reinforcing available tissue macrophages. These phagocytes were supplemented by migrating lymphocytes and blood mononuclears (monocytes) which hypertrophied to form additional macrophages. In the present study we have employed the skin window technic to study the inflammatory response to a contact allergen.

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