Abstract
1. 1. There is substantial evidence for a volume-sensitive KCl cotransport system in young human RBC. 2. 2. The KCl cotransport system becomes latent on cell maturation. 3. 3. There is a correlation between the activation of the KCl cotransporter by either pressure, NEM, ghosting or in certain anemias with disc/cup cell shape change. 4. 4. The stretch-activated KCl transporter may be coupled to some component of the cell cytoskeleton.
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