Abstract
BackgroundWe conducted a study aiming to describe Human Papillomavirus (HPV) type distribution in invasive cervical carcinoma in Uganda.Methods191 archival cervical carcinoma samples diagnosed in the Department of Pathology, Makerere University in Kampala between 1968 and 1992 were analysed using a sensitive PCR-Reverse Hybridization Line Probe Assay.ResultsOut of the 186 cases of confirmed invasive cervical cancer in the study paraffin blocks, 114 were positive for HPV DNA. Specific HPV genotypes were identifiable in 109 cases: HPV 16, 18, 31, 35, 39, 44, 45, 51, 52 and 70. These occurred as single infections in 105 cases (96.3%) and as multiple infections in 4 cases (3.7%). HPV 16 or 18 accounted for 80% (84/105) of cases with single infection.ConclusionThe results of this study confirm the role of HPV 16 and 18 in cervical cancer pathogenesis in the Ugandan population. The results suggest that the currently available HPV vaccines against HPV 16 and 18 could possibly prevent the majority of invasive cervical cancers in Uganda.
Highlights
We conducted a study aiming to describe Human Papillomavirus (HPV) type distribution in invasive cervical carcinoma in Uganda
Clinical and epidemiological studies have clearly established that infections by certain human papillomaviruses (HPVs) types are causally linked to cervical cancer development [1,2,3,4,5]
Of the 191 paraffin blocks corresponding each one to a cervical cancer cases, 186 harboured invasive cervical carcinoma cells and, according to protocol, were considered suitable for HPV detection
Summary
We conducted a study aiming to describe Human Papillomavirus (HPV) type distribution in invasive cervical carcinoma in Uganda. Clinical and epidemiological studies have clearly established that infections by certain human papillomaviruses (HPVs) types are causally linked to cervical cancer development [1,2,3,4,5]. Among the high risk HPV types, HPV 16 and 18 are recognized as the main causes of invasive cervical cancer and its precursor lesions [3]. These two viral types were found in most cases of invasive cervical cancer from 22 countries around the world [4]. Recent data shows that HPV immunization offers the greatest possibility for prevention of cervical cancer and has become an important health priority to many govern-
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