Abstract
ObjectivesPrevious reports suggest a strong association between human papillomavirus (HPV) and the etiology of laryngeal squamous cell carcinoma (LSCC). However, clinical data regarding the HPV infection rate among LSCC patients remain largely inconsistent.MethodsIn total, 674 LSCC patients from three major hospitals in Shanghai were enrolled in this study. We determined the patients' HPV infection status using immunohistochemistry and the GenoArray HPV genotyping assay and calculated their long-term survival rate using the Kaplan-Meier method.ResultsThe total P16-positive rate according to immunostaining results was 7.57% (51/674). None of the P16-negative patients were HPV-positive according to the HPV genotyping test. The rate of HPV infection among patients with LSCC was 4.9% (33/674). HPV infection was more common among nonsmokers (P<0.05), nondrinkers (P<0.05), and patients with supraglottic LSCC (P<0.05). Of the 33 HPV-positive patients, 28 (84.8%) were infected with HPV-16, 2 with HPV-18, 1 with HPV-31, 1 with HPV-33 and 1 with HPV-45. The 3-year overall survival rate and progression-free survival rate were higher in HPV-positive than HPV-negative patients, but the difference was not statistically significant (76.3% vs. 70.7%, P = 0.30 and 65.1% vs. 58.3%, P = 0.37, respectively).ConclusionHPV was not a main causal factor in LSCC carcinogenesis in this Chinese population. HPV infection did not alter patients' overall survival or progression-free survival rates in this study.
Highlights
Cancer of the larynx accounts for .3% of all cancers, making it the sixth most common cancer worldwide [1]
The established risk factors for laryngeal squamous cell carcinoma (LSCC) are tobacco and alcohol abuse; molecular evidence has supported a role for human papillomavirus (HPV), HPV-16, in the pathogenesis of LSCC [2]
Previous reports show a strong association between HPV infection and LSCC carcinogenesis
Summary
Cancer of the larynx accounts for .3% of all cancers, making it the sixth most common cancer worldwide [1]. Clinical data on the HPV infection rate among patients with LSCC remain largely inconsistent, ranging from 0% to 85% [3, 4]. This disparity is due primarily to geographical differences among the studies conducted and inadequate separation of patients with laryngeal carcinoma from patients with other cancers of the head-and-neck region, such as oropharyngeal squamous cell carcinoma (OPSCC) [5]. Differences in the analytical sensitivity and specificity of HPV genotyping methods, the limited spectrum of HPV types analyzed, and differences among HPV diagnostic criteria [6, 7] have contributed to the inconsistent results regarding HPV infection in patients with LSCC
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