Abstract
The objective of this study is to show that the presence of koilocytosis on the cervical smear is the only possibility to detect Papillomavirus infection in cervical intra-epithelial neoplasia in women living in Lubumbashi. This is a cross-sectional analytical study on the data collected from the register of women who participated in the cervix lesion screening campaign organized in Lubumbashi in March 2012 by the Congolese League Against Cancer. A total of 545 women with cervical lesions have been selected. The following results were observed: the frequency of HPV infection is 35% in Lubumbashi women. The risk of developing intraepithelial neoplasia is 38.3 times higher in women infected with HPV compared to uninfected ones (OR = 38.3, 95% CI = 16.3-90.3). HPV is predominantly present in intraepithelial neoplasia (92.7%) and this regardless of their grade: 91.9% for low-grade neoplasia and 95% for high-grade neoplasia. HPV is found in both older women and older women, respectively in 45% of women aged less than 36 years and in 55% of women aged over 36 years old. This study shows that it is necessary to put in place adequate means for the detection of HPV in order to contribute to the fight against cervical cancer in Lubumbashi.
Highlights
Papillomaviruses are a large family of small, nonenveloped DNA viruses with epithelial tropism and high resistance [1, 2]
This study aims to show that the koilocytosis on the cervical smear is the only possibility for the detection of Human papillomavirus (HPV) in intra-epithelial neoplasia in Lubumbashi and it aims to determine the frequency of HPV carriage in the population of Lubumbashi and analyze the relationship between HPV infection and cervical intraepithelial neoplasia
This is a cross-sectional analytical studybased on an analysis of cervical smear for the campaign of intra-epithelial neoplasia detection organized in March 2012 by the Congolese League against Cancer registry in Lubumbashi
Summary
Papillomaviruses are a large family of small, nonenveloped DNA viruses with epithelial tropism and high resistance [1, 2] Their genome is a circular DNA molecule of about 8,000 nucleotide pairs. They have in common a genetic organization characterized by the presence of eight genes, encoding proteins involved in the interaction with the host cell (E genes) or coding for constituents of the viral capsid (L genes) [2]. Women at risk for HPV infection are characterized by premature sexual life and multiple sexual partners or sexual promiscuity of their partner (s), suggesting the sexual transmission of a long-lasting [5] This factor leads to cellular alteration in the form of koilocytosis, identifiable on cervical smears [2]. Koilocytosis are the stigma of papillomavirus replication in the cervix [6] and are frequently
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