Abstract
The hyperchromic effect of ultraviolet spectroscopy shows that adding recombinant human neuronal tau to the solution of calf thymus DNA will promote the melting temperature (T m) from 67°C to 81°C. Similar result has been detected when adding tau to plasmid p Bluescript-II SK, by raising Tm from 75°C to 85°C. The kinetics of thermal denaturation of DNA with tau is much slower than that of control. It suggests that tau may stabilize the double helix conformation of DNA.
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