Abstract
Throughout human history, large-scale migrations have facilitated the formation of populations with ancestry from multiple previously separated populations. This process leads to subsequent shuffling of genetic ancestry through recombination, producing variation in ancestry between populations, among individuals in a population, and along the genome within an individual. Recent methodological and empirical developments have elucidated the genomic signatures of this admixture process, bringing previously understudied admixed populations to the forefront of population and medical genetics. Under this theme, we present a collection of recent PLOS Genetics publications that exemplify recent progress in human genetic admixture studies, and we discuss potential areas for future work.
Highlights
OPEN ACCESSThe funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
One of the major insights from the modern genomic era is the ubiquity of migration and admixture throughout human history [1,2,3,4,5,6,7]
Admixed populations are formed as moderate- to large-scale movements of individuals allow the exchange of genes from 2 or more previously isolated populations, creating populations with ancestors from multiple sources (Fig 1)
Summary
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
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