Abstract
Extensive exposure to solar ultraviolet radiation (UVR) is a well-recognized etiologic factor for cutaneous non-melanoma skin cancer. In this issue of the Journal, Singh et al. show that topical treatment of skin with 17-[allylamino]-17-demethoxygeldanamycin (17AAG), a heat-shock protein 90 (Hsp90) inhibitor, prevents UVR-induced squamous cell carcinomas (SCC) in mice. The inhibitory effect of 17AAG on SCC was associated with the inhibition of the UVR-induced: (i) hyperplastic response, (ii) Hsp90β-PKCε interaction, and (iii) pStat3 and pAkt expression in mouse skin.
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