Abstract
The global healthcare industry is undergoing substantial changes and adaptations to the constant decline of approved new medical entities. This decrease in internal research productivity is resulting in a major decline of patent-protected sales (patent cliff) of most of the pharmaceutical companies. Three major global adaptive trends as driving forces to cope with these challenges are evident: cut backs of internal research and development jobs in the western hemisphere (Europe and USA), following the market growth potential of Asia by building up internal or external research and development capabilities there and finally, ‘early innovation hunting’ with an increased focus on identifying and investing in very early innovation sources within academia and small start-up companies. Early innovation hunting can be done by different approaches: increased corporate funding, establishment of translational institutions to bridge innovation, increasing sponsored collaborations and formation of technology hunting groups for capturing very early scientific ideas and concepts. This emerging trend towards early innovation hunting demands special adaptations from both the pharmaceutical industry and basic researchers in academia to bridge the translation into new medicines which deliver innovative medicines that matters to the patient. This opinion article describes the different modalities of cross-fertilisation between basic university or publicly funded institutional research and the applied research and development activities within the pharmaceutical industry. Two key factors in this important translational bridge can be identified: preparation of both partnering organisations to open up for new and sometime disruptive ideas and creation of truly trust-based relationships between the different groups allowing long-term scientific collaborations while acknowledging that value-creating differences are an essential factor for successful collaboration building.
Highlights
The human population is facing substantial challenges in the coming decades with respect to their healthcare: We see an increasing size of the ageing populations, especially in the industrial countries like North America, Europe and Japan
It is important to note that the majority of innovation occurs outside of the pharmaceutical industry. With these upcoming challenges in mind, the global healthcare industry is undergoing substantial changes and adaptations to the constant decline of approved new medical entities [1-3]. This decrease in the internal research productivity within most of the larger pharmaceutical companies will prospectively result in a major decline of patent-protected sales of most of the pharmaceutical companies
Translate the innovation into the value chain of a big pharmaceutical company. This trend of early innovation hunting demands special adaptations from pharmaceutical industry, and from basic research in academia to Prepare the organisations The need for a substantial increase of innovative ideas in the health care sector has led to a higher awareness and a Recent layoffs in big pharmaceutical companies
Summary
The human population is facing substantial challenges in the coming decades with respect to their healthcare: We see an increasing size of the ageing populations, especially in the industrial countries like North America, Europe and Japan. Healthcare industry is undergoing substantial changes and adaptations to the constant decline of approved new medical entities (see Figure 1) [1-3]. This decrease in the internal research productivity within most of the larger pharmaceutical companies will prospectively result in a major decline of patent-protected sales (so called ‘patent cliff’) of most of the pharmaceutical companies. ‘Early innovation hunting’ with an opening of the pharmaceutical companies towards very early innovation sources within academia and small startup companies This can be done by different means: increased corporate funding, translational institutions to bridge innovation, increasing sponsored collaborations and technology hunting groups for front leading very early scientific ideas and concepts.
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