Abstract
Signaling from the mitochondria under a stress condition to nucleus(also known as retrograde signaling) affects expression of nucleargenes allowing for cell adaptation to impairment of mitochondrialfunctions. These adaptive changes can lead to an enhancement ofmitochondrial mass and expression of a number of mitochondrial andnuclear genes encoding for mitochondrial proteins. Mitochondria-to-nucleus signaling can be mediated by a number of molecules and oneof them are reactive oxygen species (ROS). The mitochondrial stressaffects production of ROS. On the other hand, increased ROS level hasbeen shown to be a causative factor of diseases associated withmitochondrial dysfunction. In the lecture the current understandingof mitochondrial stress mechanism will be presented.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Bioenergetics
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
