Abstract
Even though dermatologists often perform drug delivery procedures, it is necessary to assess their safety. Quantify the amount of medication delivered using the MMP drug delivery technique and outline other safety parameters. Using a simple and novel technique, we attempted to quantify the amount of medication delivered by weighing human skin samples before and after delivery. In drug delivery done on human skin using a liquid with a density of 1,271,460μg/ml (the values expressed in this manuscript are in µg), a needling density of 570perforations/cm2 , and a needling depth of 300microns, we estimate that 1,175μg/cm2 were delivered (standard deviation 601μg/cm2 , standard error 190μg/cm2 ). This result is only applicable to the protocol proposed in this study for the MMP drug delivery technique. The MMP drug delivery technique injects small amounts of medication (1,175μg/cm2 ) homogeneously into the dermis.
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