Abstract
Treating an immature tooth with necrotic pulp has been a real challenge for dentists. Large immature canals without physiologic apical closure are difficult to debride, and restoring immature teeth with thin dentin walls is a challenge due to the tooth’s susceptibility to cervical root fracture. The majority of human case studies have shown good clinical outcomes such as the absence of clinical signs and symptoms, radiographic evidence of resolution of periapical infections, continued root development, and increased canal wall thickness for immature permanent teeth with pulpal necrosis following regenerative endodontic procedures (REPs). Furthermore, REPs have the potential to heal a necrotic pulp and restore functionality. This review compiles information on the principles and clinical protocols of REPs as well as their outcomes.
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