Abstract
Two procedures for treating osteoporotic vertebral fracture have been widely adopted, but their efficacy is now in doubt. Their story suggests ways in which comparative-effectiveness research (CER) may influence medical practice and health care expenditures.
Highlights
The FDA is com mitted to pursuing these an swers with the medical and sci entific communities and will take the steps necessary to ensure that the benefits of anesthetic use in children continue to outweigh any potential risks
Disclosure forms provided by the authors are available with the full text of this arti cle at NEJM.org
From the Division of Anesthesia and Analgesia Products, Office of New Drugs (B.R., R.D.M., A.S.) and the Center for Drug Evaluation and Research (J.W.), Food and Drug Administration, Silver Spring, MD
Summary
Defining Safe Use of Anesthesia in Children implemented.
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