Abstract
The concept of cognitive reserve (CR) emerged from studies on Alzheimer disease (AD) that revealed that individuals with greater CR were less likely to show cognitive decline as AD pathology accumulated. Cognitive reserve has typically been defined as spare cognitive capacity available to buffer the effects of disease or trauma to the brain.1,2 In more recent years, a number of studies have examined CR in persons with MS (PwMS),3–6 with a recent study examining the extent to which CR might mitigate cognitive decline longitudinally.7
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