Abstract
Candida spp. proliferate as surface-associated biofilms in a variety of clinical niches. These biofilms can be extremely difficult to eradicate in healthcare settings. Cells within biofilm communities grow as aggregates and produce a protective extracellular matrix, properties that impact the ability of the host to respond to infection. Cells that disperse from biofilms display a phenotype of enhanced pathogenicity. In this review, we highlight host-biofilm interactions for Candida, focusing on how biofilm formation influences innate immune responses.
Highlights
Edited by: Juliana Campos Junqueira, São Paulo State University, BrazilReviewed by: Cheshta Sharma, The University of Texas Health Science Center at San Antonio, United States Renátó Kovács, University of Debrecen, HungarySpecialty section: This article was submitted to Fungi and Their Interactions, a section of the journal Frontiers in MicrobiologyReceived: 12 March 2020 Accepted: 03 June 2020 Published: 25 June 2020Citation: Eix EF and Nett JE (2020) How Biofilm Growth Affects Candida-HostInteractions
Murine macrophages move at rates approximately 2fold lower in response to biofilm when compared to incubation with planktonic C. albicans (Alonso et al, 2017)
The development of Candida biofilm begins with adherence to a substrate, which is followed by proliferation and the assembly of an extracellular matrix, a hallmark characteristic of mature biofilm formation (Chandra et al, 2001a; Uppuluri et al, 2010; Wall et al, 2019)
Summary
Reviewed by: Cheshta Sharma, The University of Texas Health Science Center at San Antonio, United States Renátó Kovács, University of Debrecen, Hungary. Candida spp. exhibit the propensity to proliferate as adherent biofilms (Magill et al, 2014; Nobile and Johnson, 2015) These aggregated communities exhibit resistance to antifungals as well as host immune responses, making them extremely difficult to eradicate (Chandra et al, 2001a; Donlan, 2001b; Douglas, 2003). The observation that removal of catheters decreases the risk of persistent candidemia and rate of mortality suggests that biofilm formation plays a major role in the pathogenesis of invasive candidiasis (Andes et al, 2012; Ala-Houhala and Anttila, 2020). We highlight key host interactions with Candida biofilms, describing how the host responds differently to Candida during biofilm and non-biofilm growth (Figure 1)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
