Abstract
The clinical and electroencephalographic findings for 25 patients with seizures precipitated by hot water bathing (HWE) were analyzed by researchers at Sisle Etfal Education Hospital, Istanbul, Turkey.
Highlights
In an editorial, Berg AT and Engel J Jr (Neurology 2006;67:12-13) point out that the study does not clarify whether the effects of HA are independent of age at onset, and history of febrile seizures
Hippocampal volumetry and T2 relaxometry were performed on 84 consecutive patients with partial epilepsy submitted to antiepileptic drug (AED) withdrawal after at least 2 years of seizure control, in a study at State University of Campinas-UNICAMP, Brazil
Abnormal T2 relaxation times were found in patients with more pronounced HA, and with seizure recurrence
Summary
Hippocampal volumetry and T2 relaxometry were performed on 84 consecutive patients (adolescents and adults) with partial epilepsy submitted to antiepileptic drug (AED) withdrawal after at least 2 years of seizure control, in a study at State University of Campinas-UNICAMP, Brazil. Abnormal T2 relaxation times were found in patients with more pronounced HA, and with seizure recurrence. (Cardoso TAM, Coan AC, Kobayashi E et al Hippocampal abnormalities and seizure recurrence after antiepileptic drug withdrawal. The probability of seizure remission for 5 years after AED withdrawal is 62% in patients without HA, 28% in those with HA, 62% with normal T2 signal, and 23% with abnormal T2 signal. Hippocampal atrophy and hyperintense T2-weighted signal are the MRI abnormalities commonly found in patients with mesial temporal lobe epilepsy. MRI is of value in predicting outcome following AED withdrawal, in patients with HA. The relation between HA and a diagnosis of mesial temporal lobe epilepsy was not determined in this series of patients
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