Abstract
Transdermal estradiol plus intermittent micronized progesterone over 12 months was more effective than placebo in preventing the development of clinically significant depressive symptoms in perimenopausal and early postmenopausal women, a randomized trial has found. The benefits seen from hormonal therapy did not extend to women in later stages of the menopause transition, according to the researchers. Study results were published online Jan. 10 in JAMA Psychiatry.
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