Abstract
For some time we and our associates 1 have been interested in a possible pituitary-gonadal mechanism in the pathogenesis of peptic ulcer. 1b Several clinical observations tend to support this thesis: first, peptic ulcer and its complications are less common in women than in men; second, pregnancy usually has a beneficial effect on symptoms of peptic ulcer; third, although peptic ulcer in children is rare, its incidence is equal in both sexes until maturity, when the incidence again becomes higher in the male; fourth, peptic ulcer in women not infrequently has its onset during the climacterium; fifth, the menopause may be expected to aggravate symptoms of ulcer, and sixth, a fairly high percentage of women with proved duodenal ulcer apparrently show an endocrine imbalance. It should also be noted that during the reproductive years the anterior pituitary gland is more active in the female than in the male and that
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