Abstract
THE interaction of actin and myosin which occurs during muscle contraction is regulated by changes in intracellular Ca2+ concentration. In vertebrates Ca2+ regulation is associated with troponin and tropomyosin in the thin filaments, and the myosin ATPase activity in the presence of pure actin is not Ca2+ sensitive. Most invertebrates possess a myosin-linked (thick filament) control system, usually in conjuction with actin-linked (thin filament) control1. Although the mechanism of thin filament regulation is fairly well characterised, that of thick filament control remains somewhat obscure (for reviews, see refs 2 and 3). This letter presents evidence for a structural and evolutionary relationship between proteins which have central roles in the two types of regulatory systems.
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