Abstract
The establishment of persistent infection by Sindbis virus inAedes aegypti cell cultures is independent of the initial multiplicity of infection. Persistently infected cultures yield a small plaque-forming virus mutant, SV-S, which interferes with the growth of the wild type Sindbis virus, SV-W, but not with Eastern equine encephalitis virus, another group A togavirus. The interfering capacity of SV-S was demonstrated in BHK-21 and KB cells as well as in mosquito cells.
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