Abstract
Materials and methods Were performed the comparison between the AA sequence of the GenBank: CAA94019.1-ribulose 1,5biphosphate carboxylase large subunit, partial (chloroplast) [Bauhinia forficata subsp. pruinosa] and GenBank: BAC20389.1-pancreatic beta-cell specific transcriptional activator [Homo sapiens], available in the database of NCBI with the Basic Local Alignment Search Tool (BLASTp) software. Results The homology between the ribulose 1,5-biphosphate carboxylase large subunit, partial (chloroplast) [Bauhinia forficata subsp. pruinosa] and the pancreatic beta-cell specific transcriptional activator [Homo sapiens] ranged from 48.0% to 63.0% (Fig.1).
Highlights
Diabetes mellitus (DM) is a chronic disease with an everincreasing incidence in world and has become the object of scientific research into the search for novel therapeutic alternatives
The purpose of this study is to explore the possible homology between the AA sequences of ribulose 1,5biphosphate carboxylase large subunit, partial [Bauhinia forficata subsp. pruinosa] and pancreatic beta-cell specific transcriptional activator [Homo sapiens], using databanks of proteins of National Center for Biotechnology Information (NCBI)
Bioinformatics data, suggest a possible pathogenic link between ribulose 1,5-biphosphate carboxylase large subunit, partial [Bauhinia forficata subsp. pruinosa] and pancreatic beta-cell specific transcriptional activator [Homo sapiens], and studies on this plant are important to the safe, effective development of pharmaceutical products for the treatment of diabetes
Summary
Diabetes mellitus (DM) is a chronic disease with an everincreasing incidence in world and has become the object of scientific research into the search for novel therapeutic alternatives. Bauhinia forficata Link, known locally as cow foot, has been traditionally used as tea in folk medicine of Brazil for treatment of DM
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