Abstract
Based on the results of this type of studies, studies aimed at counteracting hyperhomocysteinemia with vitamin B6, vitamin B12 and folate have been postulated, to assess the impact of this intervention on the process of atherosclerosis and decreased plasma homocysteine levels, finding favorable results in murine knockout models.
Highlights
Homocysteine is a sulfurated amino acid, deriving out of methionine from the metabolism of the methyl group [1]. It is a non-protein substance that has been associated with the dynamics of endothelial function, platelet activation, and leukocyte interaction, with the capacity to intensify the inflammatory response in the cardiovascular system, it is considered a potential cardiovascular risk marker [2]
Some studies have evaluated homocysteine in risk groups, where it has been found that the elevation of its levels is correlated as a predictor of coronary artery disease, peripheral arterial disease, ictus, deep vein thrombosis, and elevated blood pressure during pregnancy [3,4,5]
Et al [7] conducted a study analyzing homocysteine levels for one year in 3229 patients who had suffered a stroke. They found that hyperhomocysteinemia was an independent predictor of mortality (HR: 1.70; 95% CI: 1.01-2.88, p < 0.05), they predicted the risk of recurrence of stroke, mainly in those individuals with low platelet levels [7]
Summary
Homocysteine is a sulfurated amino acid, deriving out of methionine from the metabolism of the methyl group [1]. Homocysteine Levels and Cardiovascular Risk: Potential Predictor of Morbidity and Mortality *Corresponding author: Ivan David Lozada Martinez, Director of Medical-Surgical Research Center, School of Medicine, University of Cartagena, Cartagena, Colombia
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