Abstract
Neurons adapt to altered network activity through homeostatic changes in synaptic function. In this issue of Neuron, Goold and Nicoll report that chronic hyperactivation of individual CA1 pyramidal neurons drives cell-autonomous, compensatory synapse elimination via CaMKIV-dependent transcription. These findings suggest that neurons gauge their intrinsic activity to instruct homeostatic regulation of synaptic inputs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
