Abstract
Objective: to determine the impact of the degree of oxidative stress on homeostatic parameters in critically ill patients with acute poisoning by psychotropic agents (PTA). Materials and methods. The components of lipid peroxidation (LPO) and the antioxidative system (AOS), blood rheological and immunological parameters, and the markers of endogenous intoxication were studied in 43 patients with severe acute PTA intoxication before and during intensive detoxification therapy. Results. The first hours of poisoning were marked by LPO-AOS imbalance with a significant preponderance of peroxidation processes, by impaired blood viscous properties, the manifestations of secondary immunodeficiency and endogenous intoxication. There were changes in the study parameters during detoxification therapy and at the early somatogenic stage of the disease. Conclusion. In patients with acute poisoning-induced critical conditions, the degree of oxidative stress affects the time course of homeostatic changes and determines the severity of endotoxicosis at all stages of the disease.
Highlights
Цель исследования: выявить влияние выраженности окислительного стресса на показатели гомеостаза у больных в критическом состоянии при острых отравлениях психотропными препаратами
The components of lipid peroxidation (LPO) and the antioxidative system (AOS), blood rheological and immunological parameters, and the markers of endogenous intoxi cation were studied in 43 patients with severe acute psychotropic agents (PTA) intoxication before and during intensive detoxification therapy
The first hours of poisoning were marked by LPO AOS imbalance with a significant preponderance of peroxidation processes, by impaired blood viscous properties, the manifestations of secondary immunodeficiency and endogenous intox ication
Summary
Цель исследования: выявить влияние выраженности окислительного стресса на показатели гомеостаза у больных в критическом состоянии при острых отравлениях психотропными препаратами. У 43 больных с острыми отравлениями психотропными препаратами тяжелой степени изучали компоненты системы ПОЛ АОС, ге мореологические и иммунологические показатели, маркеры эндогенной интоксикации до начала интенсивной деток сикационной терапии и на фоне лечения. Objective: to determine the impact of the degree of oxidative stress on homeostatic parameters in critically ill patients with acute poisoning by psychotropic agents (PTA). In patients with acute poisoning induced critical conditions, the degree of oxidative stress affects the time course of homeostatic changes and determines the severity of endotoxicosis at all stages of the disease. В настоящее время в структуре острых экзо токсикозов наибольший удельный вес составляют острые отравления психотропными препаратами, которые дают около 10% летальных случаев при этой патологии [8]
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