Abstract
Homeobox A10 (HOXA10) belongs to the family of HOX genes, which are closely connected with embryonic development and serve important roles in various tumors. However, the role of HOXA10 in bladder cancer (BC) remains unclear. In the present study, the role of HOXA10 in BC and the underlying mechanisms by which it promotes the disease progression were investigated. Immunohistochemical analysis demonstrated that the expression of the HOXA10 protein was significantly higher in BC tissues as compared with that in adjacent normal tissues. Subsequent statistical analysis revealed that upregulation of HOXA10 was significantly associated with the pathological grade and clinical stage of BC patients. In the BC cell lines T24 and 5637, silencing of HOXA10 by small interfering RNA transfection suppressed the proliferation, migration and invasion of BC cells, and led to decreased matrix metalloproteinase-3 expression. Taken together, overexpression of HOXA10 may be associated with poor prognosis in BC, and may serve as a novel antitumor therapy target for the treatment of this disease.
Highlights
Bladder cancer (BC) is the most common malignancy of the urinary system and its incidence presents an increasing trend [1]
The results demonstrated that Homeobox A10 (HOXA10) expression was upregulated in BC tissues as compared with that in adjacent normal tissues (Fig. 1)
High HOXA10 protein expression was identified in 55.1% (43/78) of BC tissues and 38.5% (30/78) of adjacent normal tissues (P=0.035; Table I), which suggests that HOXA10 is upregulated in BC
Summary
Bladder cancer (BC) is the most common malignancy of the urinary system and its incidence presents an increasing trend [1]. Smoking and obesity are risk factors for BC [2], and genetic mutations and abnormal protein expression serve important roles in the genesis, development and progression of BC [4]. An increasing number of studies have demonstrated that HOX genes, including HOXA10, serve important roles in oncology and in the development of various tumors [7]. Previous studies have identified abnormal HOXA10 expression and reported the cancer‐promoting activities of HOXA10 in various malignant disorders, including endometrial, nasopharyngeal, gastric and breast cancer [7,8,9,10,11]. The expression and role of HOXA10 in BC has not been previously reported
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