Abstract
Dispersion-free solvent extraction using Celgard® microporous hydrophobic hollow fibers and flat membranes has been utilized for extraction/purification of fermentation-based pharmaceutical products. Extraction as well as back extraction has been studied using a pH swing procedure. Problems of emulsion formation, inherent in current processes, have been avoided to obtain stable dispersion-free operation. Very high solute recoveries and mass transfer rates have been obtained in the hollow fiber devices. Modular plant design using a series-parallel arrangement of this type of extractors and cost of existing dispersion-based devices indicate that these novel devices can compete effectively with commercial extractors.
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