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Abstract
Alport's syndrome is referred to as familial nephritis with defness. But the cause of this disease remains still unknown. Study on the heredity of HLA in a family with Alport's syndrome is considered to be meaningful in order to clarify the relationship between the disease and immunological heredity. 24 members of a Japanese family with Alport's syndrome were HLA typed by Terasaki's microcytotoxity method. According to our research there is some interrelation between AW31, BW51, DW1 and Alport's syndrome. Our result suggests the possible importance of HLA in Alport's syndrome heredity.
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