Abstract
BackgroundEnd-Stage Renal Disease (ESRD) is a worldwide public health problem. Currently, many genome-wide association studies have suggested a potential association between human leukocyte antigen (HLA) and ESRD by uncovering a causal relationship between HLA and glomerulonephritis. However, previous studies, which investigated the HLA polymorphism and its association with ESRD, were performed with the modest data sets and thus might be limited. On the other hand, few researches were conducted to tackle the Chinese population with ESRD. Therefore, this study aims to detect the susceptibilities of HLA polymorphism to ESRD within the Cantonese community, a representative southern population of China.MethodsFrom the same region, 4541 ESRD patients who were waiting for kidney transplantation and 3744 healthy volunteer bone marrow donors (controls) were randomly chosen for this study. Polymerase chain reaction-sequence specific primer method was used to analyze the HLA polymorphisms (including HLA-A, HLA-B and HLA-DRB1 loci) in both ESRD patients and controls. The frequencies of alleles at these loci and haplotypes were compared between ESRD patients and controls.ResultsA total of 88 distinct HLA alleles and 1361 HLA A-B-DRB1 haplotypes were detected. The frequencies of five alleles, HLA-A*24, HLA-B*55, HLA-B*54, HLA-B*40(60), HLA-DRB1*04, and one haplotype (HLA-A*11-B*27-DRB1*04) in ESRD patients are significantly higher than those in the controls, respectively.ConclusionsFive HLA alleles and one haplotype at the HLA-A, HLA-B and HLA-DRB1 loci appear to be associated with ESRD within the Cantonese population.
Highlights
With a high incidence, end-stage renal disease (ESRD) becomes a worldwide public health problem [1]
In order to enrich the knowledge of human leukocyte antigen (HLA) polymorphism in the Cantonese population and detect its susceptibilities to End-Stage Renal Disease (ESRD), the frequencies of alleles at the HLA-A, -B and -DRB1 loci and haplotypes in both ESRD patients who are waiting for kidney transplantation and healthy volunteer bone marrow donors from the same region of Southern China were investigated
Characteristics of patients and control donors A total of 4541 Cantonese ESRD patients were selected from the database of the tissue typing center affiliated with the Transplantation Center of Nanfang Hospital, including 2754 (60.65%) males
Summary
End-stage renal disease (ESRD) becomes a worldwide public health problem [1]. In China, there is a rising incidence of ESRD, too. The number of the registered ESRD patients who were treated by hemodialysis was 41,755 in 1999, and this number was even more than 120,000 in 2008 [3]. The annual incidence of ESRD that needed hemodialysis therapy was estimated to be as high as 36.1 per million population (pmp) in China [4]. End-Stage Renal Disease (ESRD) is a worldwide public health problem. Previous studies, which investigated the HLA polymorphism and its association with ESRD, were performed with the modest data sets and might be limited. This study aims to detect the susceptibilities of HLA polymorphism to ESRD within the Cantonese community, a representative southern population of China
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