Abstract
This report describes studies of interferon production in the human mixed lymphocyte culture. Similar levels of interferon were detectable in two-way, unidirectional, and double-irradiated mixed lymphocyte culture combinations. Following an initial lag period of 1–2 days interferon production showed a peak response on days 3–4 and, in most combinations, was detectable through day 7 of the mixed lymphocyte culture. Interferon-gamma was the predominant type of interferon produced, along with a minor component of interferon activity detectable in some culture combinations which appeared similar to interferon-alpha. Interferon was not produced in HLA identical sibling combinations except for one brother-sister pair who were the donor and recipient of a kidney allograft. Interferon was produced in sibling and unrelated individual combinations that expressed HLA-A, HLA-B, or HLA-DR region incompatibility, with higher concentrations of interferon detectable in the HLA-DR region incompatible combinations.
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