Abstract
The argument of this article starts with three key theoretical postulates: First, regional-scale explanation differs in important respects from either aggregate macroeconomic studies of development at the national level or microeconomic and business historical studies of individual firms. Second, neoclassical economic theory is unsuitable as a basis for the analysis of regional economic dynamics, and a different framework, called adjustment theory, should be used in its place. Third, utilization of adjustment theory in the historical geographical domain leads directly to the deployment of both the concepts and methods of geographical information science as the foundation for empirical inquiry.
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