Abstract
Background and objectiveThe present study intended to investigate the histopathological efficacy of obstetric gels on the healing of vaginal lacerations in rats. To the best of our knowledge, this is the first such study.Materials and methodsTwenty-one female Wistar albino rats were divided into three groups, comprising seven animals per group. The first group (group 1) was the control group, the second (group 2) was the polyvinyl iodine (PI) group, and the third group (group 3) was the obstetric gel (OG) group. In all three groups, a vaginal incision was made with a No. 10 scalpel, and the incision site was sutured with a 3-0 Vicryl suture. In the control group, the incision site was left for routine healing. The incision site was washed with PI in the PI group and with OG in the OG group. After 15 days, vaginal tissues were obtained from all three groups for histopathological examination. In addition, immunohistochemistry staining was performed using caspase 3 and fibrillin 1 antibodies.ResultsThere was no significant difference between the groups in terms of congestion, vascular proliferation, and inflammation stages in the examinations performed on the vaginal wall. However, the amount of collagen and elastic fibers increased during the remodeling and fibrosis phase, and the fibrillin 1 score increased in immunohistochemistry staining (p < 0.001).ConclusionIt has been shown in rat vaginal tissue that obstetric gels do not have negative effects on wound healing; however, they contribute to wound healing by positively affecting the fibrosis stage.
Highlights
The second stage of labor is the period from full dilation of the cervix to birth and is the shortest stage of labor [1]
The amount of collagen and elastic fibers increased during the remodeling and fibrosis phase, and the fibrillin 1 score increased in immunohistochemistry staining (p < 0.001)
The present study evaluated the effect of obstetric gel (OG) on the healing of perineal lacerations using multiple histopathological criteria and found that OG contributed to the proliferation and remodeling stages of wound healing
Summary
The second stage of labor is the period from full dilation of the cervix to birth and is the shortest stage of labor [1]. A history of difficult delivery due to a prolonged second stage of labor is one of the most important reasons for vaginal tissue lacerations [2,3]. Shortening the second stage of labor might help preserve the integrity of the perineum and prevent possible negative maternal and neonatal consequences. Episiotomy, use of forceps/vacuum, or positional methods, such as lateral positioning, are used to shorten the second stage of labor, minimize the development of perineal trauma, and protect the integrity of the perineum [5]. Lavender oil, and aloe vera gel have been used as lubricants in various studies to facilitate vaginal delivery [6,7]. The present study intended to investigate the histopathological efficacy of obstetric gels on the healing of vaginal lacerations in rats. To the best of our knowledge, this is the first such study
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