Abstract
Purpose: To evaluate the pathological effect associated with the exposure of viscerals and testicular tissues of albino rats to BPA and DEHP.
 Methods: A total of sixty adult male Wistar rats weighing 200 – 250 g were divided into four (4) groups of 15 rats per cage in a sanitized environment. Group I animals received normal rodent pellet and water and served as untreated group. Thereafter, the rats in the second group (II) were administered 5 mg/kg per day of BPA mixed with rodent pellet orally; group III received 0.5 mg/kg daily dose of DEHP mixed with rodent pellet; while group IV received orally mixture of 0.5 mg/kg of BPA and 0.5 mg/kg DEHP + pelleted rodent feed. The rats were fed and water provided regularly for 30 days; finally, the animals were weighed and sacrificed by cranial dislocation.
 Result: BPA and DEHP resulted in significant (p < 0.05) weight losses, inflammation and fatty deposits in the liver, degenerated bowman capsule and glomeruli of the kidneys, lung oedema, and deteriorated leydig cells in testes.
 Conclusion: The results suggest that BPA and DEHP cause significant weight loss and are injurious to the cellular make-up of rat tissues, which may be the same in higher animals.
Highlights
Di (2-ethyhexyl)phthalate (DEHP) and Bisephenol A (BPA) broadly occur in plastic and constant introduction to human body, which happens through dietary means by way of indiscriminate consumption, inward breathing, dermal and intravenous route by means of consumer products and medical devices is worrisome
The need to guarantee that the plastic items we use does not contain risky synthetic substances that presents as danger to our body tissues and organs, prompted our examining the impacts of these chemical substances (BPA and DEHP) on some organs and testicular tissues of Wistar rats
Experimental groups II, III and IV were on daily treatment by BPA and DEHP combined with rodent pellet and were given to animals morning and evening using the results of the acute toxicity test as a gold standard
Summary
Di (2-ethyhexyl)phthalate (DEHP) and Bisephenol A (BPA) broadly occur in plastic and constant introduction to human body, which happens through dietary means by way of indiscriminate consumption, inward breathing, dermal and intravenous route by means of consumer products and medical devices is worrisome. Di (2ethylhexyl)phthalate (DEHP) was categorized under the Non-deleterious Drinking Water and Toxic Enforcement Act of 1986 (generally known as Proposition 65, classified at Health and Safety Code Section 25249.5 et seq.), which is known to the state to cause reproductive lethality (formative and male reproductive injurious effects), effective October 24, 2003 [8]. This situation hinged on a proper identification of DEHP as being instrumental to varieties of developmental and male reproductive defects following the order of the National Institute for Occupational Safety and Health [8]. A total of 60 male adult Wistar rats weighing between 200-250g were purchased from animal house, University of Nigeria, Enugu Campus
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