Abstract
BackgroundIn selected patients with peritoneal carcinomatosis from colorectal cancer prognosis can be improved by hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery. The aim of this study was to evaluate the tumor response of peritoneal carcinomatosis in tumor-bearing rats treated with HIPEC.MethodsCC531 colon carcinoma (2,5 × 106 cells), implanted intraperitoneally in Wag/Rija rats, was treated by hyperthermic intraperitoneal chemotherapy. After 10 days of tumor growth the animals were randomized into five groups of six animals each: group I: control (n = 6), group II: sham operated animals (n = 6), group III: hyperthermic intraperitoneal perfusion (HIP) without cytostatic drugs, group IV: HIPEC with mitomycin C in a concentration of 15 mg/m2 (n = 6), group V: mitomycin C i.p. alone in a concentration of 10 mg/m2 (n = 6). After 10 days the extent of tumor spread and histological outcome were analysed by autopsy.ResultsAll control animals developed extensive intraperitoneal tumor growth. Histological tumor load was significantly reduced in group III and group V and was lowest in group IV. In group II tumor load was significantly higher than in group I. Implanted metastases were significantly decreased in group IV compared with group I and group II.ConclusionThese findings indicate that HIPEC is an effective treatment for peritoneal carcinomatosis in this animal model. HIPEC reduced macroscopic and microscopic intraperitoneal tumor spread.
Highlights
In selected patients with peritoneal carcinomatosis from colorectal cancer prognosis can be improved by hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery
The median survival time after manifestation of peritoneal carcinomatosis is about 6–9 months [2]
The feasibility of intraperitoneal therapy has been demonstrated by several groups which used this technique in combination with cytoreductive surgery to treat peritoneal carcinomatosis [4,5]
Summary
In selected patients with peritoneal carcinomatosis from colorectal cancer prognosis can be improved by hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery. A treatment strategy for these patients would be hyperthermic intraperitoneal chemotherapy (HIPEC). The first clinical hyperthermic chemotherapy in the treatment of peritoneal carcinomatosis (PC) was performed by Spratt et al in 1980 [3]. This therapeutic design is regarded as one of the best options for the therapy of peritoneal metastasis from gastrointestinal carcinoma. The feasibility of intraperitoneal therapy has been demonstrated by several groups which used this technique in combination with cytoreductive surgery to treat peritoneal carcinomatosis [4,5]
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