Abstract
AbstractIn order to clarify the factors leading to coronary arteritis in Kawasaki's disease (mucocutaneous lymph node syndrome, MCLS), the coronary arteries of 24 control infant cases without a history of MCLS were carefully studied.The media of the coronary artery at the point where it branches from the aorta consists of an inner layer of smooth muscle continuous from the aorta and an outer circular muscle of the coronary artery proper. In all 24 cases, fibrous intimal thickening and distortion of the inner medial layer were found.Since the site of these changes corresponded well to the most frequent location of arteritis in MCLS, these changes may play an important role in the development of arteritis. These changes were thought to be the result of physiological accommodation against neonatal hemorheological changes.
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