Abstract
The “clubs“, found at the perifery of the “sulfur granules” in Actinomyces infection, are composed chiefly of a highly polymerized basic protein rich in guanidyl, indole, and phenolic groups; sulfhydryl groups are absent. The clubs appear to be made of a material actively secreted by the filaments. It is hypothesized that some product or products of animal protein decomposition which are metabolized by the actinomycete trigger and maintain club formation in vivo, and that the club prevents phagocytosis or enzymatic digestion of the filaments on the one hand but proscribes further growth of the filaments on the other. New growth of the parasite takes place by extension of non-clubbed filaments at the perifery of the granule or by deposition of coccoid elements phagocytized by leucocytes.
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