Abstract
MANY humoral agents are capable of modulating synaptic transmission in sympathetic ganglia and it has been proposed that a variety of receptors are present at the ganglionic synapse (see Haefely1). There are thus many possible modulatory mechanisms at this synapse, some of which have a dual nature, the same substance being able both to facilitate and to depress ganglionic transmission by an action on two different populations of receptors. We wish to present evidence that histamine, like the catecholamines2 and 5-hydroxytryptamine (serotonin)3, has a dual action at the ganglionic synapse.
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