Abstract
Theta rhythms temporally coordinate sequences of hippocampal place cell ensembles during active behaviors, while sharp wave-ripples coordinate place cell sequences during rest. We investigated whether such coordination of hippocampal place cell sequences is disrupted during error trials in a delayed match-to-place task. As a reward location was learned across trials, place cell sequences developed that represented temporally compressed paths to the reward location during the approach to the reward location. Less compressed paths were represented on error trials as an incorrect stop location was approached. During rest periods of correct but not error trials, place cell sequences developed a bias to replay representations of paths ending at the correct reward location. These results support the hypothesis that coordination of place cell sequences by theta rhythms and sharp wave-ripples develops as a reward location is learned and may be important for the successful performance of a spatial memory task.
Highlights
Theta rhythms temporally coordinate sequences of hippocampal place cell ensembles during active behaviors, while sharp wave-ripples coordinate place cell sequences during rest
We set out to investigate whether spatial trajectories represented by temporally compressed sequences of spikes from ensembles of place cells recorded from hippocampal subfield CA1 differed between correct and error trials of a delayed match-to-place task
These results suggest that correct behavioral performance on a spatial memory task is associated with the development of coordinated sequences of place cells during theta rhythms and sharp wave-ripples that represent trajectories extending toward a learned reward location
Summary
Theta rhythms temporally coordinate sequences of hippocampal place cell ensembles during active behaviors, while sharp wave-ripples coordinate place cell sequences during rest. During rest periods of correct but not error trials, place cell sequences developed a bias to replay representations of paths ending at the correct reward location These results support the hypothesis that coordination of place cell sequences by theta rhythms and sharp wave-ripples develops as a reward location is learned and may be important for the successful performance of a spatial memory task. Place cell sequences developed a significant bias to replay a path that terminated at the correct reward location during correct trials but not during error trials Taken together, these results suggest that correct behavioral performance on a spatial memory task is associated with the development of coordinated sequences of place cells during theta rhythms and sharp wave-ripples that represent trajectories extending toward a learned reward location
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