Abstract
Objective: Obesity is an important global public health problem that is associated with many chronic diseases and is increasing day by day in our country as well as in the world. The aim of this study is to compare malondialdehyde (MDA) and reduced glutathione (GSH) in some rat tissues due to obesity and hypoxia. 
 Material and Methods: In our study 24 male Sprague Dawley rats were used. Rats were divided into four groups (n:6) as standard diet/normal oxygen, standard diet/low oxygen, high-fat diet/normal oxygen, and high-fat diet/low oxygen. For the study, a special cage with low oxygen level of 17-18% in the closed system was used. Weight gain of 20-25% was achieved in obese rats. MDA and GSH levels were measured in liver, kidney and brain organ tissues of rats.
 Results: In our study it was determined that there were significant increases in the amount of MDA and GSH. It was observed that MDA and GSH had a protective effect against hypoxia and obesity in liver and brain tissue, but not in kidney tissue.
 Conclusion: As a result of our research we think that MDA and GSH may support the current criteria in the diagnosis and/or treatment of obesity and will contribute greatly to more comprehensive analyzes to be made in the future.
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